Genome Integrity

The genomes consist of the total amount of genetic material required to encode human life's blueprint. For normal cell division, normal function of our tissues and organs, healthy ageing, and the prevention of diseases such as cancer, successful preservation of genome integrity and stability are important. Processes that regulate the preservation of genome integrity include sensing, signalling and repairing DNA damage, chromatin and chromosome DNA damage storage, cell cycle checkpoint regulation, and cell death control. Many of the fundamental aspects of the integrity of the genome — such as how cells feel and handle DNA damage — are still not well understood.

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