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Sayyed Morteza Hosseini

Sayyed Morteza Hosseini

Advanced Center for Biotechnology, UAE

Title: Current status and perspectives of stem cell and cloning technologies in regenerative medicine and disease therapeutics

Biography

Biography: Sayyed Morteza Hosseini

Abstract

Without any doubt, regenerative medicine is the major innovation in health care because of its great capacity to repair or replacement of damaged/diseased human cells, tissues or organs to restore normal function. Despite past limited success in the clinical translation of several promising preclinical results, the spectacular recent progress in the field of stem cells and somatic cell nuclear transfer (SCNT) technologies has laid the promising foundation for cell based therapies of disease which cannot be cured by conventional medicines. 

The rapid advancement of stem cells technology can be illustrated by the progression of human embryonic stem cells (hESCs), induced pluripotent stem cells (iPS) and the use of pluripotent vs. somatic and of allogenic vs. autologous stem cells for a series of cell based therapies which have received Food and Drug Administration (FDA) approval and are now commercially available. On the other hand, the rapid advancement of SCNT technology can be illustrated by technical improvements, development of human and monkey cloned embryos and ESCs thereof as well as disease modeling and production of new lines of genetically modified cloned animals for xenotransplantation. Here, these advances and other regenerative medicine approaches currently being studied in preclinical and clinical settings will be reviewed. The popular view and the ethical issues will be addressed and finally, the perspectives, challenges and directions for the future of regenerative will be discussed.

 

Recent Publications :

  1. Lee SE, Hyun H, Park MR, Choi Y, Son YJ, Park YG, Jeong SG, Shin MY, Ha HJ, Hong HS, Choi MK, Im GS, Park EW, Kim YH, Park C, Kim EY, Park SP (2017) Production of transgenic pig as an Alzheimer's disease model using a multi-cistronic vector system. PLoS One 6;12(6).
  2. Liu Z, Cai Y, Wang Y, Nie Y, Zhang C, Xu Y, Zhang X, Lu Y, Wang Z, Poo M, Sun Q (2018) Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer. Cell [Epub ahead of print].
  3. Yao X, Liu Z, Wang X, Wang Y, Nie YH, Lai L, Sun R, Shi L, Sun Q, Yang H (2018) Generation of knock-in cynomolgus monkey via CRISPR/Cas9 editing. Cell Res  [Epub ahead of print].
  4. Tachibana M, Amato P, Sparman M, Gutierrez NM, Tippner-Hedges R, Ma H, Kang E, Fulati A, Lee HS, Sritanaudomchai H, Masterson K, Larson J, Eaton D, Sadler-Fredd K, Battaglia D, Lee D, Wu D, Jensen J, Patton P, Gokhale S, Stouffer RL, Wolf D, Mitalipov S (2013) Human embryonic stem cells derived by somatic cell nuclear transfer. Cell 153:1228-38.
  5. Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-76.
  6. Maoa AS, Mooneya DJ (2015) Regenerative medicine: Current therapies and future directions. PNAS 112: 14452-14459.