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Maya N Gaiozishvili

Maya N Gaiozishvili

Ivane Javakhishvili Tbilisi State University,Georgia

Title: GST Genes (GSTM1 and GSTT1) Polymorphism in Georgian Population

Biography

Biography: Maya N Gaiozishvili

Abstract

The glutathione S-transferase (GST) enzyme system constitutes a family of multifunctional enzymes which play an important role in biotransformation and detoxification of many different xenobiotic. Human cytosolic GSTs are polymorphic, and have ethnic-dependent polymorphism frequencies, and have been associated with several types of diseases. In the double-null variant of GSTM1 and GSTT1 are respectively associated with a higher risk of different forms of liver injury, cancer, cardiovascular diseases etc[1-3].

Comparisons between GST null genotype frequencies in the worldwide populations show different patterns in Asian, African, and European populations.

Some detailed studies of GST variants in various geographic regions can increase the knowledge about relationship between the ethnicity and the prevalence of certain diseases[4]. Thus, it becomes necessary to consider the genotypic differences for reducing the risk of anti-tuberculosis drug-induced Liver injury[5].

The aim of our research was to determine the polymorphism of GSTM1 and GSTT1 genes in Georgian population.

In the studies was be used peripheral blood samples obtained from individuals randomly selected groups. The GSTM1 and GSTT1 null genotypes was investigated with the help of an Ese-Quant tube scanner-by SmartAmp Method[6].

The study of GST genes polymorphism in Georgian population revealed that 88% of individuals have positive genotypes of GSTT1 and GSTM1, and 12% of individuals have null genotype only by one of this gene - GSTT1 or GSTM1.  Out of these, GSTT1(-) null genotype was observed in 4% of individuals and GSTM1(-) have 8% of individuals. It should also be noted that there was not observed double null genotype (GSTT1(-), GSTM1(-)) in investigated group of individuals.

In the next stage of our research we will investigate the relation between the null genotypes of GSTM1 and GSTT1 and risk of development drug-induced hepatotoxicity in TB patients from Georgianpopulation.

The results will play the most important role in personalized medicine, in the appointment and management of drugs and for prevention of adverse drug reactions   in patients of Georgian population.

Recent Publications (minimum 5)

  1. Rafiee L., Saadat I., Saadat M. (2010) Glutathione S-transferase polymorphisms (GSTM1, GSTT1 and GSTO2) in three Iranian population. Mol Biol Rep.  37, 155-158.
  2. Wang J.,Zou L., Huang S., et al. (2010) Genetics polymorphism of glutation-S-transferaze genes GSTM1and GSTT1 and risk coronary heart disease. Mutagenesis. 25:365-369.
  3. Nafissi S., Saadat I., Saadat M. (2011) Genetics polymorphism of glutation-S-transferaze Z1 in Iranian population. Mol Biol Rep. 38:3391-3394.
  4. Piacentini S., Polimanti R., Porreca F. (2011) GSTT1 and GSTM1 gene polymorphisms in European and African populations. Mol Biol Rep. 38:1225–1230.
  5. Gupta V., Singh M., Amarapurkar D. et al. (2013) Association of GST null genotypes with anti-tuberculosis drug induced hepatotoxicity in Western Indian population. Ann Hepatol. 12(6):959-965.
  6. Okada R, Ishizu Y, Endo R, Lezhava A, et al. (2010) Direct and rapid genotyping of glutathione-S-transferase M1 and T1 from human blood specimens using the SmartAmp2 method. Drug Metab Dispos.  Oct; 38(10):1636-1639.